You can not select more than 25 topics Topics must start with a letter or number, can include dashes ('-') and can be up to 35 characters long.
 
 
 
 
root 5404e09047 first commit 2 months ago
..
cram first commit 2 months ago
htscodecs/htscodecs first commit 2 months ago
htslib first commit 2 months ago
m4 first commit 2 months ago
os first commit 2 months ago
LICENSE first commit 2 months ago
Makefile first commit 2 months ago
README first commit 2 months ago
bcf_sr_sort.c first commit 2 months ago
bcf_sr_sort.h first commit 2 months ago
bgzf.c first commit 2 months ago
builddir_vars.mk.in first commit 2 months ago
config.guess first commit 2 months ago
config.h first commit 2 months ago
config.h.in first commit 2 months ago
config.mk.in first commit 2 months ago
config.sub first commit 2 months ago
configure first commit 2 months ago
configure.ac first commit 2 months ago
errmod.c first commit 2 months ago
faidx.c first commit 2 months ago
fuzz_settings.h first commit 2 months ago
header.c first commit 2 months ago
header.h first commit 2 months ago
hfile.c first commit 2 months ago
hfile_gcs.c first commit 2 months ago
hfile_internal.h first commit 2 months ago
hfile_libcurl.c first commit 2 months ago
hfile_s3.c first commit 2 months ago
hfile_s3_write.c first commit 2 months ago
hts.c first commit 2 months ago
hts_expr.c first commit 2 months ago
hts_internal.h first commit 2 months ago
hts_os.c first commit 2 months ago
hts_time_funcs.h first commit 2 months ago
htscodecs_bundled.mk first commit 2 months ago
htscodecs_external.mk first commit 2 months ago
htslib.mk first commit 2 months ago
htslib.pc.in first commit 2 months ago
htslib_vars.mk first commit 2 months ago
kfunc.c first commit 2 months ago
kstring.c first commit 2 months ago
md5.c first commit 2 months ago
multipart.c first commit 2 months ago
plugin.c first commit 2 months ago
probaln.c first commit 2 months ago
realn.c first commit 2 months ago
regidx.c first commit 2 months ago
region.c first commit 2 months ago
sam.c first commit 2 months ago
sam_internal.h first commit 2 months ago
sam_mods.c first commit 2 months ago
simd.c first commit 2 months ago
synced_bcf_reader.c first commit 2 months ago
tbx.c first commit 2 months ago
textutils.c first commit 2 months ago
textutils_internal.h first commit 2 months ago
thread_pool.c first commit 2 months ago
thread_pool_internal.h first commit 2 months ago
vcf.c first commit 2 months ago
vcf_sweep.c first commit 2 months ago
vcfutils.c first commit 2 months ago
version.sh first commit 2 months ago

README

HTSlib is an implementation of a unified C library for accessing common file
formats, such as SAM, CRAM, VCF, and BCF, used for high-throughput sequencing
data. It is the core library used by samtools and bcftools.

See INSTALL for building and installation instructions.

Please cite this paper when using HTSlib for your publications:

HTSlib: C library for reading/writing high-throughput sequencing data
James K Bonfield, John Marshall, Petr Danecek, Heng Li, Valeriu Ohan, Andrew Whitwham, Thomas Keane, Robert M Davies
GigaScience, Volume 10, Issue 2, February 2021, giab007, https://doi.org/10.1093/gigascience/giab007

@article{10.1093/gigascience/giab007,
author = {Bonfield, James K and Marshall, John and Danecek, Petr and Li, Heng and Ohan, Valeriu and Whitwham, Andrew and Keane, Thomas and Davies, Robert M},
title = "{HTSlib: C library for reading/writing high-throughput sequencing data}",
journal = {GigaScience},
volume = {10},
number = {2},
year = {2021},
month = {02},
abstract = "{Since the original publication of the VCF and SAM formats, an explosion of software tools have been created to process these data files. To facilitate this a library was produced out of the original SAMtools implementation, with a focus on performance and robustness. The file formats themselves have become international standards under the jurisdiction of the Global Alliance for Genomics and Health.We present a software library for providing programmatic access to sequencing alignment and variant formats. It was born out of the widely used SAMtools and BCFtools applications. Considerable improvements have been made to the original code plus many new features including newer access protocols, the addition of the CRAM file format, better indexing and iterators, and better use of threading.Since the original Samtools release, performance has been considerably improved, with a BAM read-write loop running 5 times faster and BAM to SAM conversion 13 times faster (both using 16 threads, compared to Samtools 0.1.19). Widespread adoption has seen HTSlib downloaded \\>1 million times from GitHub and conda. The C library has been used directly by an estimated 900 GitHub projects and has been incorporated into Perl, Python, Rust, and R, significantly expanding the number of uses via other languages. HTSlib is open source and is freely available from htslib.org under MIT/BSD license.}",
issn = {2047-217X},
doi = {10.1093/gigascience/giab007},
url = {https://doi.org/10.1093/gigascience/giab007},
note = {giab007},
eprint = {https://academic.oup.com/gigascience/article-pdf/10/2/giab007/36332285/giab007.pdf},
}